TS-IN-6
TS-IN-6 (Compound 10) is a thymidylate synthase (TS) inhibitor with an IC50 value of 0.54 μM, demonstrating significant antiproliferative activity. TS-IN-6 induces G1 phase cell cycle arrest and apoptosis (marked by substantial increases in both early and late apoptotic rates) and shows potential for research on cancers such as colon, breast, and liver cancers[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Thymidylate Synthase
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
CC1=CC=CC=C1N2C(SCC3=CN(C4=CC=C(F)C=C4F)N=N3)=NN=C2COC5=CC=C6C=CC=CC6=C5
Molecular Formula
C29H22F2N6OS
Molecular Weight
540.59
References & Citations
[1]Alam, M. M., et al. New Triazole Hybrids as Anticancer Agents Targeting Thymidylate Synthase: Synthesis, Biological and Molecular Docking Studies. Polycyclic Aromatic Compounds, 1–16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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