GSK3β-IN-2

GSK3β-IN-2 (Compound S01) is the inhibitor for GSK3β with an IC50 of 0.35 nM. GSK3β-IN-2 activates Wnt/β-catenin signaling pathway, promotes neurogenesis and neurite growth. GSK3β-IN-2 inhibits Aβ-induced tau hyperphosphorylation at Ser396, reduces the formation of neurofibrillary tangles. GSK3β-IN-2 ameliorates Alzheimer's Disease in zebrafish model[1].

Product Specifications

CAS Number

[3068378-38-8]

UNSPSC

12352005

Target

GSK-3; Wnt; β-catenin

Related Pathways

PI3K/Akt/mTOR; Stem Cell/Wnt

Field of Research

Neurological Disease

Concentration

10mM

Purity

98.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CNC2=NC=C(C3=CC=CC=C3)C=C21)NC4=C(C5=CC=CC=C5)C=CN=C4

Molecular Formula

C25H18N4O

Molecular Weight

390.44

References & Citations

[1]Xun QQ, et al., Identification of a novel pyrrolo[2,3-b]pyridine compound as a potent glycogen synthase kinase 3β inhibitor for treating Alzheimer's disease. J Enzyme Inhib Med Chem. 2025 Dec;40 (1) :2466846.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GSK-3β

Available Sizes

Curated Selection

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