CCR6 antagonist 2
CCR6 antagonist 2 (Compound 20c) is the antagonist for CCR6 with a Ki of 1.1 nM. CCR6 antagonist 2 inhibits CCL20-induced calcium ion influx (IC50 = 4.9 nM), inhibits the chemotactic migration of CCR6+ T cells (IC50 = 190 nM) [1].
Product Specifications
UNSPSC
12352005
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(N(C)C)C1=NC=CC(NC2=C(N[C@@H]3[C@H](C)CCCC3)C(C2=O)=O)=C1O
Molecular Formula
C19H24N4O4
Molecular Weight
372.42
References & Citations
[1]Gerstenberger BS, et al., Conformational Role of Methyl in the Potency of Cyclohexane-Substituted Squaramide CCR6 Antagonists. J Med Chem. 2025 Feb 27;68 (4) :4818-4828.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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