ALKBH5-IN-5

ALKBH5-IN-5 (compound 18l) is an ALKBH5 inhibitor, exhibiting highly selective inhibitory effect on ALKBH5 with an IC50 of 0.62 μM. ALKBH5-IN-5 exerts a strong antiproliferative effect on NB4 cells with an IC50 of 0.63 μM. ALKBH5-IN-5 binds with ALKBH5 with a Kd of 804 nM. ALKBH5-IN-5 directly targets ALKBH5 in cells and alters m6A levels on mRNA, blocks the related downstream signal pathways, promotes differentiation, and induces Apoptosis. ALKBH5-IN-5 exerts excellent in vivo antitumor activity with TGITV values of 66.3%[1].

Product Specifications

CAS Number

[140481-05-6]

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK)

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Concentration

10mM

Purity

99.65

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C=C1)N(CCC2=CC=CC=C2OC)C1=O

Molecular Formula

C13H13NO3

Molecular Weight

231.25

References & Citations

[1]Wu H, et al. Discovery of Covalent and Cell-Active ALKBH5 Inhibitors with Potent Antileukemia Effects In Vivo. Angew Chem Int Ed Engl. 2025 Feb 20:e202424928.