HDAC11-IN-2
HDAC11-IN-2 (compound B6) is a high selective Histone Deacetylase 11 (HDAC11) inhibitor. HDAC11-IN-2 inhibits HDAC11 and HDAC8 with IC50s of 51.1 x10-3 μM and 5 μM, respectively. HDAC11-IN-2 inhibits denovolipogenesis (DNL) and promotes fatty acid oxidation, thus mitigating hepaticlipid accumulation and pathological symptoms in MASLD mice. HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at Thr172 through the inhibition of HDAC11, consequently modulating DNL and fatty acid oxidation in the liver[1].
Product Specifications
CAS Number
[2919766-97-3]
UNSPSC
12352005
Target
AMPK; HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Purity
99.52
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCOCCCCCNNC(C1=CC=C(CNC(C2=CC=CC=C2)=O)C=C1)=O
Molecular Formula
C25H35N3O3
Molecular Weight
425.56
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK α1β1γ1; HDAC11; HDAC8
Available Sizes
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