MEK1-IN-1
MEK1-IN-1 (Compound M15) is a MEK1 inhibitor with an IC50 of 10.29 nM. MEK1-IN-1 can inhibit the proliferation and migration, induce apoptosis of tumor cells. MEK1-IN-1 has good liver microsomal stability. MEK1-IN-1 can be used for the research of solid tumors[1].
Product Specifications
UNSPSC
12352005
Target
MEK
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
IC1=CC=C(NC2=C(C(NC3CCN(C(/C=C/C4=CC5=C(C=C4)OCO5)=O)CC3)=O)C=CC(F)=C2F)C(F)=C1
Molecular Formula
C28H23F3IN3O4
Molecular Weight
649.40
References & Citations
[1]Zeng J, et al. Design and Synthesis of Novel MEK Inhibitors for the Treatment of Solid Tumors. Chem Biol Drug Des. 2025 Feb;105 (2) :e70067.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MEK1
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