MP-010

MP-010 is a FKBP12 ligand that regulates cytosolic calcium by stabilizing RyR channel activity. MP-010 promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice, as evidenced by improved motor coordination, increased integrity of neuromuscular junctions, and significantly enhanced survival of spinal motor neurons. MP-010 can be used for research in the field of neurological diseases[1].

Product Specifications

CAS Number

[3024617-59-9]

UNSPSC

12352005

Target

Calcium Channel; FKBP

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CN(C)CCN1N=NC(CS(C2=CC=C(OC)C=C2)=O)=C1

Molecular Formula

C14H20N4O2S

Molecular Weight

308.40

References & Citations

[1]Moreno-Martinez L, et al. Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1G93A amyotrophic lateral sclerosis (ALS) mice. Br J Pharmacol. 2025 Feb 13.