Thalidomide-O-CH2-CO-NH-C2-PEG2-NH-Boc
Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc is a conjugate of E3 ligase ligand and linker, which contains Thalidomide-based CEREBLON ligand and PEG inker. Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc can be used to synthesize PROTAC degrader JB300.
Product Specifications
CAS Number
1957235-73-2
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(OC(C)(C)C)NCCOCCOCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O
Molecular Formula
C26H34N4O10
Molecular Weight
562.57
References & Citations
[1]Bozilovic, et al. "Novel, highly potent PROTACs targeting AURORA-A kinase." Current Research in Chemical Biology 2 (2022) : 100032.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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