Ebio3
Ebio3 is a selective potassium channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. Ebio3 binds to the KCNQ2 channel through its hydrophobic tail, causing the S6 helix to move inward, which leads to the closure of the inner gate. The inhibitory effect of Ebio3 is also effective in pathogenic mutants of KCNQ2 (such as R75C and I238L), where it can inhibit outward currents by more than 80%. Ebio3 is expected to be used in the research of neurological diseases such as epilepsy[1].
Product Specifications
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
C#CCN1N=C(NC(C(CCC)CCC)=O)C2=CC=CC(OC(F)F)=C21
Molecular Formula
C19H23F2N3O2
Molecular Weight
363.40
References & Citations
[1]Li J, et al. Small molecule inhibits KCNQ channels with a non-blocking mechanism. Nat Chem Biol. 2025 Jan 15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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