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LSQ-28

LSQ-28 is an orally active HDAC3 inhibitor with an IC50 of 42 nM, and exhibits potent anticancer, antiproliferative, antimigratory, anti-invasive, and antiwound healing activities. LSQ-28 can be utilized in cancer research[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Smiles

CCCNNC(C1=CC=C(CN2C3=C(C4=CC=CC=C24)C(C5=CC=CC=N5)=NC6=C3C=CC=C6)C=C1)=O

Molecular Formula

C31H27N5O

Molecular Weight

485.58

References & Citations

[1]Li S, et al. Discovery of Highly Potent and Orally Bioavailable Histone Deacetylase 3 Inhibitors as Immunomodulators and Enhancers of DNA-Damage Response in Cancer Therapy. J Med Chem. 2025 Jan 28.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC3

Frequently Asked Questions

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