PDE4-IN-26

PDE4-IN-26 (Compound A5) is an orally active and highly selective PDE4 inhibitor. PDE4-IN-26 has anti-inflammatory activity and can inhibit the phosphorylation of p38 MAPK. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 can improve pulmonary inflammation, injury and fibrosis, promote sputum secretion and relieve cough in mice. PDE4-IN-26 can be used for the research of lung injury-related diseases[1].

Product Specifications

UNSPSC

12352005

Target

P38 MAPK; Phosphodiesterase (PDE)

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

FC(OC1=C(OCC2CC2)C=C(C3=NC4=C(N3)C=CC=C4C(NC5=NC=CS5)=O)C=C1)F

Molecular Formula

C22H18F2N4O3S

Molecular Weight

456.47

References & Citations

[1]Li M, et al. Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury. J Med Chem. 2025 Feb 13;68 (3) :3837-3857.