NLRP3-IN-70
NLRP3-IN-70 (Compound 5m) is an NLRP3 inflammasome inhibitor with low oral bioavailability. NLRP3-IN-70 can directly bind to the NACHT domain of the NLRP3 protein and block the interaction of NLRP3 and ASC, thus inhibiting ASC oligomerization and NLRP3 inflammasome assembly. NLRP3-IN-70 can be used in the research of sepsis and nonalcoholic steatohepatitis[1].
Product Specifications
CAS Number
[1997362-01-2]
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=C(C2=C3C4=C(C(C)(CCC4)C)C=C2)OC=C1C(N5CCOCC5)=O)C3=O
Molecular Formula
C23H23NO5
Molecular Weight
393.43
References & Citations
[1]Zhu K, et al. Peripheral Evolution of Tanshinone IIA and Cryptotanshinone for Discovery of a Potent and Specific NLRP3 Inflammasome Inhibitor. J Med Chem. 2025 Feb 13;68 (3) :3460-3479.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NLRP3
Curated Selection
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