NLRP3-IN-70

NLRP3-IN-70 (Compound 5m) is an NLRP3 inflammasome inhibitor with low oral bioavailability. NLRP3-IN-70 can directly bind to the NACHT domain of the NLRP3 protein and block the interaction of NLRP3 and ASC, thus inhibiting ASC oligomerization and NLRP3 inflammasome assembly. NLRP3-IN-70 can be used in the research of sepsis and nonalcoholic steatohepatitis[1].

Product Specifications

CAS Number

[1997362-01-2]

UNSPSC

12352005

Target

NOD-like Receptor (NLR)

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O=C(C1=C(C2=C3C4=C(C(C)(CCC4)C)C=C2)OC=C1C(N5CCOCC5)=O)C3=O

Molecular Formula

C23H23NO5

Molecular Weight

393.43

References & Citations

[1]Zhu K, et al. Peripheral Evolution of Tanshinone IIA and Cryptotanshinone for Discovery of a Potent and Specific NLRP3 Inflammasome Inhibitor. J Med Chem. 2025 Feb 13;68 (3) :3460-3479.