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HDAC3-IN-6

HDAC3-IN-6 (Compound SC26) is a selective HDAC3 inhibitor with an IC50 of 53 nM. HDAC3-IN-6 dose-dependently induces the expression of PD-L1. HDAC3-IN-6 induces more pronounced Apoptosis and production of ROS. HDAC3-IN-6 exhibits high antitumor efficacy against colorectal cancer[1].

Product Specifications

CAS Number

3070532-72-5

UNSPSC

12352005

Target

Apoptosis; HDAC; PD-1/PD-L1; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Smiles

O=C(C1=CC=C(CNC(C2=CN=C(C3=CC=C4OC=CC4=C3)N2)=O)C=C1)NNCCC

Molecular Formula

C23H23N5O3

Molecular Weight

417.46

References & Citations

[1]Sun Z, et al. Discovery of Novel Hydrazide-Based HDAC3 Inhibitors as Epigenetic Immunomodulators for Cancer Immunotherapy. J Med Chem. 2025 Feb 13;68 (3) :3048-3064.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

HDAC1; HDAC3

Frequently Asked Questions

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