PI3Kδ/BET-IN-1
PI3Kδ/BET-IN-1 (compound 10b) shows excellent and balanced activities against PI3Kδ (IC50 = 112 nM) and BRD4-BD1 (IC50 = 19 nM) and exhibits strong antiproliferative activities in DLBCL cells[1].
Product Specifications
CAS Number
3054869-10-9
UNSPSC
12352005
Target
Epigenetic Reader Domain; PI3K
Related Pathways
Epigenetics; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
CN1C=C(C2=NC(N3CCOCC3)=C4SC(CN5CCC(C(C)(O)C)CC5)=CC4=N2)C6=C(C1=O)NC=C6
Molecular Formula
C27H34N6O3S
Molecular Weight
522.66
References & Citations
[1]Kai Ran, et al. Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as the First Bifunctional PI3Kδ Isoform Selective/Bromodomain and Extra-Terminal Inhibitors. J Med Chem. 2025 Jan 24.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4; PI3Kδ
Frequently Asked Questions
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