PI3Kδ/BET-IN-1

PI3Kδ/BET-IN-1 (compound 10b) shows excellent and balanced activities against PI3Kδ (IC50 = 112 nM) and BRD4-BD1 (IC50 = 19 nM) and exhibits strong antiproliferative activities in DLBCL cells[1].

Product Specifications

CAS Number

[3054869-10-9]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PI3K

Related Pathways

Epigenetics; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

CN1C=C(C2=NC(N3CCOCC3)=C4SC(CN5CCC(C(C)(O)C)CC5)=CC4=N2)C6=C(C1=O)NC=C6

Molecular Formula

C27H34N6O3S

Molecular Weight

522.66

References & Citations

[1]Kai Ran, et al. Design, Synthesis, and Biological Evaluation of Thieno[3,2-d]pyrimidine Derivatives as the First Bifunctional PI3Kδ Isoform Selective/Bromodomain and Extra-Terminal Inhibitors. J Med Chem. 2025 Jan 24.