HDAC6-IN-52

HDAC6-IN-52 (EX.1) is a potent inhibitor of HDAC6, with the inhibitory rate of 100% at 10 μM. HDAC6-IN-52 plays an important role in central nervous system diseases including neurodegenerative diseases such as Alzheimer’s disease andprogressive supranuclear palsy[1].

Product Specifications

CAS Number

[2636786-68-8]

UNSPSC

12352005

Target

HDAC

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Neurological Disease

Smiles

O=C1C2=CC(C3=NN=C(O3)C(F)F)=CC=C2CN1[C@@H]([C@H](C4=CC=CC=N4)O)C5=NC=CC=C5

Molecular Formula

C23H17F2N5O3

Molecular Weight

449.41

References & Citations

[1]Ahmed F. Abdel-Magid. Potential of Histone Deacetylase 6 Inhibitors as a Treatment of Neurodegenerative Diseases. ACS Medicinal Chemistry Letters January 25, 2025