NUAK1-IN-1

NUAK1-IN-1 (Compound 9) is a NUAK1 (IC50 of 5.012 nM) and CDK4 inhibitor. NUAK1-IN-1 can be used in cancer, neurodevelopmental disorders and Alzheimer's disease research[1].

Product Specifications

UNSPSC

12352005

Target

AMPK; CDK

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR

Field of Research

Cancer; Neurological Disease

Smiles

CC1=CC(N(C2=C1C=NC(NC3=CC=C(C=C3)N4CC5CC(N5C)C4)=N2)C6CCCC6)=O

Molecular Formula

C25H30N6O

Molecular Weight

430.55

References & Citations

[1]Rooney TPC, et al. Development of the Pyrido[2,3-d]pyrimidin-7 (8H) -one Scaffold toward Potent and Selective NUAK1 Inhibitors. ACS Med Chem Lett. 2025 Jan 25;16 (2) :327-335.