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JQ-1 (carboxylic acid) -NH-C2-NH-AMPRO-222

Selected Variant

HY-172126

Size: 1 Each

JQ-1 (carboxylic acid) -NH-C2-NH-AMPRO-222 incorporates a ligand for BRD4, and a PROTACs linker that can be used in the synthesis of PROTAC BRD4 Degrader-29.

Product Specifications

UNSPSC

12352005

Target

Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=NN=C2N1C3=C(C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NCCNC(C5=CC=C(SCCC#CC(C6CCOCC6)N7CCC(N)CC7)C=C5)=O)=O)C(C)=C(C)S3

Molecular Formula

C43H51ClN8O3S2

Molecular Weight

827.50

References & Citations

[1]Andrew McGown, et al. Use of Aldehyde–Alkyne–Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers. ACS Medicinal Chemistry Letters

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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