JQ-1 (carboxylic acid) -NH-C2-NH-AMPRO-222
JQ-1 (carboxylic acid) -NH-C2-NH-AMPRO-222 incorporates a ligand for BRD4, and a PROTACs linker that can be used in the synthesis of PROTAC BRD4 Degrader-29 (HY-172124) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; Target Protein Ligand-Linker Conjugates
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=NN=C2N1C3=C(C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NCCNC(C5=CC=C(SCCC#CC(C6CCOCC6)N7CCC(N)CC7)C=C5)=O)=O)C(C)=C(C)S3
Molecular Formula
C43H51ClN8O3S2
Molecular Weight
827.50
References & Citations
[1]Andrew McGown, et al. Use of Aldehyde–Alkyne–Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers. ACS Medicinal Chemistry Letters
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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