PROTAC BRD4 Degrader-29
PROTAC BRD4 Degrader-29 (compound 7a) is a potent PROTACs degrader of BRD4, with the DC50 of 89.4 nM. PROTAC BRD4 Degrader-29 plays an important role in cancer research (Pink: ligand for target protein (HY-13030) ; Black: linker (HY-172125) ; Blue: E3 ligase ligand (HY-103597) ) [1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
CC1=NN=C2N1C3=C(C(C4=CC=C(Cl)C=C4)=N[C@H]2CC(NCCNC(C5=CC=C(SCCC#CC(C6CCOCC6)N7CCC(NC(COC8=CC=CC9=C8C(N(C%10CCC(NC%10=O)=O)C9=O)=O)=O)CC7)C=C5)=O)=O)C(C)=C(C)S3
Molecular Formula
C58H61ClN10O9S2
Molecular Weight
1141.75
References & Citations
[1]Andrew McGown, et al. Use of Aldehyde–Alkyne–Amine Couplings to Generate Medicinal Chemistry-Relevant Linkers. ACS Medicinal Chemistry Letters
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4
Curated Selection
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