SGC-CDKL5/GSK3
CDKL5/GSK3-IN-1 (Compound 2) is a potent and selectivity chemical probe for CDKL5/GSK3.CDKL5/GSK3-IN-1 has potent inhibition of CDKL5 and GSK3α/β, with IC50 values of 4.6, 24 and 9.5 nM for CDKL5, GSK3β and GSK3α, respectively, in the NanoBRET assay. CDKL5/GSK3-IN-1 can be used for the research of CNS diseases[1].
Product Specifications
CAS Number
[844442-32-6]
UNSPSC
12352005
Target
GSK-3
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
98.72
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=CC(F)=CC(F)=C1)NC2=CNN=C2C(NC3CCNCC3)=O
Molecular Formula
C16H17F2N5O2
Molecular Weight
349.34
References & Citations
[1]Ong HW, et al. A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective. bioRxiv [Preprint]. 2023 Feb 10:2023.02.09.527935.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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