Mitochondria modulator-2

Mitochondria modulator-2 (Compound Ir1) induces the depolarization of mitochondrial membrane potential, induces ROS generation, inhibits cell migration of A549, arrests the cell cycle at G2/M phase, and induces apoptosis in A549[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

[F-][P+5]([F-])([F-])([F-])([F-])[F-].[F-][P+5]([F-])([F-])([F-])([F-])[F-].C1(C=CC=C2)=C2[Ir+]34([N]5=C6C7=[N]3C=CC=C7C8=C(NC(C9=CC=C(OCCCC[P+](C%10=CC=CC=C%10)(C%11=CC=CC=C%11)C%12=CC=CC=C%12)C=C9)=N8)C6=CC=C5)(C%13=C(C=CC=C%13)C%14=[N]4C=CC=C%14)[N]%15=CC=CC=C1%15

Molecular Formula

C63H50F12IrN6OP3

Molecular Weight

1420.23

References & Citations

[1]Fu H, et al., Triphenylphosphine-modified cyclometalated iridiumIII complexes as mitochondria-targeting anticancer agents with enhanced selectivity. Bioorg Chem. 2025 Feb;155:108148.