BGC4
BGC4 is a biphenyl-based gold (III) complex. BGC4 inhibits human recombinant thioredoxin reductase (TrxR) with an IC50 of 10.7 μM, exhibits cytotoxicity (IC50 for MDA-MB-231 is 5.4 μM), and induces apoptosis. BGC4 exhibits antitumor efficacy in mouse models[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; TrxR
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC(C)(C1=CC2=C(C=C1)C3=CC=C(C=C3[Au]2(C4N(C=CN4C5=NC=CC(C(F)(F)F)=C5)C)Cl)C(C)(C)C)C
Molecular Formula
C30H33AuClF3N3
Molecular Weight
725.02
References & Citations
[1]Remadna E, et al., Synthesis and Biological Evaluation of a New Biphenyl-Based Organogold (III) Complex with In Vitro and In Vivo Anticancer Activity. J Med Chem. 2025 Jan 23;68 (2) :1755-1771.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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