Apoptosis inducer 35

Apoptosis inducer 35 (Compound 6) is a multi-targeted inhibitor, that reduces the expressions of EGFR, AKT, ERK and P38-MAPKα. Apoptosis inducer 35 inhibits the proliferation of cancer cell A549 and Jurkat, arrests the cell cycle at S phase, and induces apoptosis[1].

Product Specifications

UNSPSC

12352005

Target

Akt; Apoptosis; EGFR; ERK; p38 MAPK

Related Pathways

Apoptosis; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Field of Research

Cancer

Smiles

CCOC(CSC1=NN=C(CSC2=NN=C(C3=CC4=C(C=CC=C4)N3)N2N)N1C5=CC=C(Cl)C=C5)=O

Molecular Formula

C23H21ClN8O2S2

Molecular Weight

541.05

References & Citations

[1]Boraei ATA, et al., Synthesis of new functionalized bioactive S-substituted indolyl-triazoles as cytotoxic and apoptotic agents through multi-targeted kinase inhibition. Bioorg Chem. 2025 Jan 10;156:108154.