DNA Gyrase-IN-15

DNA Gyrase-IN-15 (Compound 11) is an antimicrobial agent and inhibitor of DHPS and DNA gyrase, with IC50s of 1.73 and 0.07 µM, respectively. DNA Gyrase-IN-15 shows antimicrobial activity against Enterococcus faecalis (MIC of 15.62 µg/mL), Acinetobacter baumannii, Enterobacter species (MIC of 7.81 µg/mL), Pseudomonas aeruginosa, Klebsiella pneumoniae and Staphylococcus aureus. DNA Gyrase-IN-15 also shows antibiofilm activity against Enterococcus faecalis[1].

Product Specifications

UNSPSC

12352005

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Smiles

O=C(CC(SC1)=NC1=O)N/N=C(C2=CC=CC=C2)/C3=C(C4=CC=CC=C4)C(C(OCC)=O)=C(NC5=CC=CC=C5)S3

Molecular Formula

C31H26N4O4S2

Molecular Weight

582.69

References & Citations

[1]Abd El-Mawgoud HK, et al. Synthesis of tetra-substituted thiophene derivatives as potential Hits combating antibiotic resistant bacteria ESKAPE. Bioorg Chem. 2025 Jan 8;155:108101.