TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. TGFβRI-IN-7 inhibits SMAD2/3 phosphorylation and H22 cell viability with IC50 values of 12 and 65 nM, respectively. TGFβRI-IN-7 shows anti-tumor efficacy in a xenograft model of H22 cells, with TGI of 79.6 %[1].
Product Specifications
UNSPSC
12352005
Target
TGF-β Receptor
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CN(CCN1C=C(C=N1)C2=CC3=NC=CC(OC4=CN(N=C4C5CCOCC5)C6CC6)=C3C=C2)C
Molecular Formula
C27H32N6O2
Molecular Weight
472.58
References & Citations
[1]Siyuan Liu, et al. Synthesis and biological evaluation of 4- ((3- (tetrahydro-2H-pyran-4-yl) -1H-pyrazol-4-yl) oxy) quinoline derivatives as novel potential transforming growth factor-β type 1 receptor inhibitors for hepatocellular carcinoma. Bioorg Chem. 2025 Jan 10:155:108156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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