HPK1-IN-56

HPK1-IN-56 (Compound A29) is a HPK1 inhibitor (IC50: 2.70 nM) . HPK1-IN-56 inhibits downstream p-SLP76 (IC50: 8.1 nM in Jurkat T cells) . HPK1-IN-56 induces the production of IL-2 in human PBMCs. HPK1-IN-56 has anticancer effect, enhances T-cell killing ability and the antitumor efficacy of anti-PD-1 antibody[1].

Product Specifications

CAS Number

[2901054-39-3]

UNSPSC

12352005

Target

Interleukin Related; MAP4K

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway

Field of Research

Cancer; Inflammation/Immunology

Smiles

COC1=C(NC2=NN=C3C(N)=CC(C4=C(C)C(N)=CN=C4)=CC3=N2)C=C5CN(C)CCC5=C1

Molecular Formula

C24H26N8O

Molecular Weight

442.52

References & Citations

[1]Mao J, et al. Discovery of 1,2,4-benzotriazine derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Bioorg Chem. 2025 Jan 10;156:108158.