HPK1-IN-56
HPK1-IN-56 (Compound A29) is a HPK1 inhibitor (IC50: 2.70 nM) . HPK1-IN-56 inhibits downstream p-SLP76 (IC50: 8.1 nM in Jurkat T cells) . HPK1-IN-56 induces the production of IL-2 in human PBMCs. HPK1-IN-56 has anticancer effect, enhances T-cell killing ability and the antitumor efficacy of anti-PD-1 antibody[1].
Product Specifications
CAS Number
2901054-39-3
UNSPSC
12352005
Target
Interleukin Related; MAP4K
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Field of Research
Cancer; Inflammation/Immunology
Smiles
COC1=C(NC2=NN=C3C(N)=CC(C4=C(C)C(N)=CN=C4)=CC3=N2)C=C5CN(C)CCC5=C1
Molecular Formula
C24H26N8O
Molecular Weight
442.52
References & Citations
[1]Mao J, et al. Discovery of 1,2,4-benzotriazine derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Bioorg Chem. 2025 Jan 10;156:108158.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP4K1/HPK1; MAP4K2/GCK; MAP4K3/GLK; MAP4K4/HGK; MAP4K5/KHS1; MAP4K6/MINK1
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