Anti-NASH agent 2

Anti-NASH agent 2 (compound 21) is an inhibitor of de novo adipogenesis activity and α-SMA gene expression. Anti-NASH agent 2 improves hepatic steatosis, edema, inflammatory infiltrates, and liver fibrosis in NASH mouse models[1].

Product Specifications

CAS Number

[3028778-28-8]

UNSPSC

12352005

Target

PPAR

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Field of Research

Metabolic Disease; Inflammation/Immunology

Smiles

[H][C@@]12[C@@H](O)CC3=C([C@H](C)CCN4C=C(CC(C)C)N=N4)CC[C@]3(C)[C@@]1(C)CC[C@@]5([H])C(C(CC[C@]25C)=O)(C)C

Molecular Formula

C32H51N3O2

Molecular Weight

509.77

References & Citations

[1]Yu NR, et al. Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis. Bioorg Chem. 2025 Jan 7;155:108132.