EGFR-IN-143

EGFR-IN-143 (Compound 5f) is a potent EGFR inhibitor with an IC50 value of 0.15 μM. EGFR-IN-143 induces apoptosis by arresting the cell cycle in the G2/M phase. EGFR-IN-143 has antitumor activity[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; EGFR

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

CCCN1N=C(C(C(N/N=C\C2=CC=C(C(OC)=C2)O)=O)=N1)NC3=CC=C(C=C3)Cl

Molecular Formula

C20H21ClN6O3

Molecular Weight

428.87

References & Citations

[1]Nawareg NA, et al. Exploring 1,2,3-triazole-Schiff's base hybrids as innovative EGFR inhibitors for the treatment of breast cancer: In vitro and in silico study. Bioorg Chem. 2025 Jan 3;155:108106.