P38-α MAPK-IN-8

P38-α MAPK-IN-8 (Compound 13) is a lipophilic cationic derivative. p38-α MAPK-IN-8 is cytotoxic to various tumor cells, and can induce cell cycle arrest, apoptosis, increase reactive oxygen species (ROS) production, and induce mitochondrial membrane potential depolarization. The antitumor activity of p38-α MAPK-IN-8 may be related to p38α MAPK pathway, which can be used in the study of cancer[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; p38 MAPK; Reactive Oxygen Species (ROS)

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Field of Research

Cancer

Smiles

C[C@]12CC[C@]3([C@@](CC=C4C[C@@H](OC(CCC[P+](C5=CC=CC=C5)(C6=CC=CC=C6)C7=CC=CC=C7)=O)CC[C@@]43C)([C@@]1(C[C@]8([H])O[C@]9(CC[C@@H](C)CO9)[C@@H](C)[C@@]82[H])[H])[H])[H].[Br-]

Molecular Formula

C49H62BrO4P

Molecular Weight

825.89

References & Citations

[1]An RF, et al. Design, synthesis and cytotoxic activity of novel lipophilic cationic derivatives of diosgenin and sarsasapogenin. Bioorg Med Chem Lett. 2025 Jan 6;119:130094.