CSRC/BCR-ABL-IN-1

CSRC/BCR-ABL-IN-1 (compound 21b) is a potent Bcr-Abl and C-Src inhibitor with IC50 values of 56.2, 101 nM for Bcr-Abl, C-Src, respectively. cSRC/BCR-ABL-IN-1 shows cytotoxicity activity[1].

Product Specifications

UNSPSC

12352005

Target

Bcr-Abl; Src

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Smiles

C=CC(N(C1=C(C=NC2=CC(OCCCN3CCN(CC3)C)=C(C=C21)OC)C#N)C4=CC(OC)=C(C=C4Cl)Cl)=O

Molecular Formula

C29H31Cl2N5O4

Molecular Weight

584.49

References & Citations

[1]Lin C, et al. Disrupted target binding with acryloyl group as potential Bcr-Abl/C-Src dual kinase inhibitor optimization strategies with maintained antitumor activity. Bioorg Med Chem Lett. 2025 Jan 13;119:130105.