AMPK-IN-6
AMPK-IN-6 (compound 13a) is potent AMPK inhibitor with an IC50 value of 0.093 µM. AMPK-IN-6 induces apoptosis and inhibits autophagy. AMPK-IN-6 shows antiproliferative activity. AMPK-IN-6 has the potential for the research of pulmonary arterial hypertension[1].
Product Specifications
UNSPSC
12352005
Target
AMPK; Apoptosis; Autophagy
Related Pathways
Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Smiles
N[C@@H]1CC[C@@H](CC1)NC2=C(C(NC=C2)=O)C3=NC4=C(N3)C=CC(F)=C4
Molecular Formula
C18H20FN5O
Molecular Weight
341.38
References & Citations
[1]Tan W, et al. A novel pyridine-2-one AMPK inhibitor: Discovery, mechanism, and in vivo evaluation in a hypoxic pulmonary arterial hypertension rat model. Eur J Med Chem. 2025 Jan 12;286:117266.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-172094/
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPK
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