AMPK-IN-6

AMPK-IN-6 (compound 13a) is potent AMPK inhibitor with an IC50 value of 0.093 µM. AMPK-IN-6 induces apoptosis and inhibits autophagy. AMPK-IN-6 shows antiproliferative activity. AMPK-IN-6 has the potential for the research of pulmonary arterial hypertension[1].

Product Specifications

UNSPSC

12352005

Target

AMPK; Apoptosis; Autophagy

Related Pathways

Apoptosis; Autophagy; Epigenetics; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Smiles

N[C@@H]1CC[C@@H](CC1)NC2=C(C(NC=C2)=O)C3=NC4=C(N3)C=CC(F)=C4

Molecular Formula

C18H20FN5O

Molecular Weight

341.38

References & Citations

[1]Tan W, et al. A novel pyridine-2-one AMPK inhibitor: Discovery, mechanism, and in vivo evaluation in a hypoxic pulmonary arterial hypertension rat model. Eur J Med Chem. 2025 Jan 12;286:117266.