HIV-1 inhibitor-80

HIV-1 inhibitor-80 (compound M44) is an HIV-1 inhibitor with an EC50 of 5-148 nM. HIV-1 inhibitor-80 shows good metabolic stability and cytotoxicity in human plasma and human liver microsomes[1].

Product Specifications

UNSPSC

12352005

Target

HIV

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

COC1=C(/C(C2=CC=NC(NC3=CC=C(C#N)C=C3)=N2)=N\N)C=CC(C4=CC=C(C#N)C=C4)=C1

Molecular Formula

C26H19N7O

Molecular Weight

445.48

References & Citations

[1]Xiao-Mei Chen, et al. Structure-based discovery of novel diarylpyrimidines as potent and selective Non-Nucleoside reverse transcriptase inhibitors: From CH (CN) -Biphenyl-Diarylpyrimidines to CNNH2-Biphenyl-Diarylpyrimidines. Eur J Med Chem. 2025 Jan 12:285:117271.