MASP-2-IN-1

MASP-2-IN-1 (Compound 77) is the inhibitor for mannan-binding lectin-associated serine protease (MASP), that inhibits MASP2 and MASP3 with IC50 of 11.4 nM and 13.2 µM. MASP-2-IN-1 exhibits a weak inhibitory activity against hERG with an IC50 of 175 µM. MASP-2-IN-1 reveals a poor stability in mouse plasma with a half-life of 4.4 hours[1].

Product Specifications

UNSPSC

12352005

Target

Potassium Channel; Ser/Thr Protease

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Smiles

NC1=NC(C2=CC=C(C=C2)CNC(CC3=NC=C(C=N3)NS(=O)(C4=CC=CC=C4)=O)=O)=CN1

Molecular Formula

C22H21N7O3S

Molecular Weight

463.51

References & Citations

[1]Nakhla M C, et al. Small Molecule Inhibitors of Mannan-Binding Lectin-Associated Serine Proteases-2 and-3[J]. European Journal of Medicinal Chemistry, 2025: 117238.