Tubulin/MMP-IN-3

Tubulin/MMP-IN-3 (Compound 15j) is the dual inhibitor for tubulin polymerization and MMP, and inhibits MMP-2 and MMP-9 with IC50 of 21.13 μM and 19.24 μM. Tubulin/MMP-IN-3 inhibits NF-κB signaling pathway, causes mitochondrial dysfunction and the apoptosis through a mitochondrial-dependent pathway. Tubulin/MMP-IN-3 exhibits antiproliferative activity in a variety of cancer cells, arrests the cell cycle at G2/M phase, and exhibits antitumor efficacy in mouse models[1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin; MMP; NF-κB

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

CCOP(OCC)(C(NC1=CC=C(CC(OC2=C(OC)C=CC(/C=C/C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=C2)=O)C=C1)C4=CC([N+]([O-])=O)=CC=C4)=O

Molecular Formula

C38H41N2O12P

Molecular Weight

748.71

References & Citations

[1]Li G, et al., Discovery of novel dual tubulin and MMPs inhibitors for the treatment of lung cancer and overcoming drug resistance. Eur J Med Chem. 2025 Jan 9;285:117249.