VDR agonist 3
VDR agonist 3 (Compound E15) is a potent vitamin D receptor (VDR) agonist. VDR agonist 3 can effectively inhibit HSC activation through VDR. VDR agonist 3 significantly reduces liver fibrosis without causing hypercalcemia in a CCl4-induced mouse liver fibrosis model[1].
Product Specifications
UNSPSC
12352005
Target
VD/VDR
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Inflammation/Immunology
Smiles
CCC(OC(C1=C[C@@H](O)[C@@H](O)[C@H](O)C1)=O)C2=CC(OCCCC(CC)(O)CC)=CC=C2
Molecular Formula
C24H36O7
Molecular Weight
436.54
References & Citations
[1]Gao F, et al. Design, synthesis, and anti-liver fibrosis activity of novel non-steroidal vitamin D receptor agonists based on open-ring steroid scaffold. Eur J Med Chem. 2025 Jan 9;286:117250.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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