TrxR-IN-7
TrxR-IN-7 (14f) is a potent thioredoxin reductase (TrxR) inhibitor with an IC50 value of 3.5 μM. TrxR-IN-7 shows antiproliferative activity. TrxR-IN-7 induces apoptosis and ROS generation[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Reactive Oxygen Species (ROS) ; TrxR
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
N#CC1=CC=C([C@@]2(O)CCC[C@@]3(C)CC(C(C=C4)=O)=C(C[C@]32[H])C4=O)C=C1
Molecular Formula
C22H21NO3
Molecular Weight
347.41
References & Citations
[1]Huang B, et al. Synthesis and discovery of simplified pleurotin analogs bearing tricyclic core as novel thioredoxin reductase inhibitors. Eur J Med Chem. 2025 Jan 6;285:117242
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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