COX-2-IN-55
COX-2-IN-55 (compound 1) is an orally active, Celecoxib (HY-14398) -based analog with broad-spectrum anticancer activity and weak COX-2 inhibition. COX-2-IN-55 specifically inhibits SERCA2, increases caspase-3 cleavage and DR5 levels, thereby activating GRP78 and inhibiting the development of triple-negative breast cancer (TNBC) . COX-2-IN-55 can also downregulate the levels of angiogenic markers VEGF-α and IL-8, inhibiting the formation of microvessels[1].
Product Specifications
CAS Number
[2649115-80-8]
UNSPSC
12352005
Target
Calcium Channel; Caspase; VEGFR
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; Neuronal Signaling; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=S(NC1=CC(N)=CC=C1)(C2=CC=C(N3N=C(C(F)(F)F)C=C3C4=C(C)C=CC(C)=C4)C=C2)=O
Molecular Formula
C24H21F3N4O2S
Molecular Weight
486.51
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; VEGFR1/Flt-1
Available Sizes
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