RIPK3-IN-6
RIPK3-IN-6 (compound 1) is a type I RIPK3 inhibitor with poor selectivity for the RIPK family, especially for RIPK2 activity[1].
Product Specifications
CAS Number
[955879-75-1]
UNSPSC
12352203
Target
RIP kinase
Related Pathways
Apoptosis
Field of Research
Cancer
Purity
98.03
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C)C(NC2=CC=NC3=CC(C4=NC=CC=C4)=CC=C23)=C1
Molecular Formula
C21H17N3O
Molecular Weight
327.38
References & Citations
[1]Rodriguez DA, et al. Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis. Cell Death Differ. 2016 Jan;23 (1) :76-88.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
RIPK3
Available Sizes
Curated Selection
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