VU6002703
VU6002703 (Compound 17) is a BBB-penetrable M4 mAChR positive allosteric modulator (PAM) with an EC50 of 0.6 μM for hM4. VU6002703 can be used for neuropsychiatric and rare genetic CNS disorders research[1].
Product Specifications
CAS Number
[1934241-32-3]
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=C(C)SC2=NC=NC(N3CCC(CC3)OC4=CN=C(C)C=C4)=C21
Molecular Formula
C19H22N4OS
Molecular Weight
354.47
References & Citations
[1]Xiong B, et al. Strategies for Structural Modification of Small Molecules to Improve Blood-Brain Barrier Penetration: A Recent Perspective. J Med Chem. 2021 Sep 23;64 (18) :13152-13173.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR4
Curated Selection
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