KARI 201 (hydrochloride)
KARI 201 hydrochloride is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 hydrochloride is a ghrelin receptor agonist. KARI 201 hydrochloride improves neuropathological features of Alzheimer's disease[1].
Product Specifications
CAS Number
[2376132-24-8]
UNSPSC
12352005
Target
GHSR; Phospholipase
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.94
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(CO)(CO)C(N=N1)=CN1CCCCCCCCC.Cl
Molecular Formula
C14H29ClN4O2
Molecular Weight
320.86
References & Citations
[1]Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proc Natl Acad Sci U S A. 2022 Jan 18;119 (3) :e2115082119.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
038891-PE 200 µL
NELF, CT (NELF, Nasal embryonic luteinizing hormone-releasing hormone factor) (PE) discontinued
Ask
View Details 
MBS2035729-01 0.1 mL
FITC-Linked Polyclonal Antibody to FMS Like Tyrosine Kinase 3 (Flt3)
Ask
View Details