KARI 201
KARI 201 is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC50 of 338.3?nM. KARI 201 is a ghrelin receptor agonist. KARI 201 improves neuropathological features of Alzheimer's disease[1].
Product Specifications
CAS Number
[2376132-22-6]
UNSPSC
12352005
Target
GHSR; Phospholipase
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
NC(CO)(CO)C(N=N1)=CN1CCCCCCCCC
Molecular Formula
C14H28N4O2
Molecular Weight
284.40
References & Citations
[1]Park MH, et al. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice. Proc Natl Acad Sci U S A. 2022 Jan 18;119 (3) :e2115082119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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