5β-Cholestane-3α,7α,12α,25-tetrol
5β-Cholestane-3α,7α,12α,25-tetrol (3α,7α,12α,25-Tetrahydroxycoprostane) is a bile acid alcohol. 5β-Cholestane-3α,7α,12α,25-tetrol is a GPBAR1 (also known as TGR5) activator (EC50: 1.36 μM) . 5β-Cholestane-3α,7α,12α,25-tetrol is the predominant bile-alcohol disease marker present in patients with Cerebrotendinous xanthomatosis (CTX) [1][2].
Product Specifications
CAS Number
[18866-87-0]
Product Name Alternative
3α,7α,12α,25-Tetrahydroxycoprostane
UNSPSC
12352211
Target
Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCCC(C)(O)C)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C
Molecular Formula
C27H48O4
Molecular Weight
436.67
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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