5β-Cholestane-3α,7α,12α,25-tetrol

5β-Cholestane-3α,7α,12α,25-tetrol (3α,7α,12α,25-Tetrahydroxycoprostane) is a bile acid alcohol. 5β-Cholestane-3α,7α,12α,25-tetrol is a GPBAR1 (also known as TGR5) activator (EC50: 1.36 μM) . 5β-Cholestane-3α,7α,12α,25-tetrol is the predominant bile-alcohol disease marker present in patients with Cerebrotendinous xanthomatosis (CTX) [1][2].

Product Specifications

CAS Number

[18866-87-0]

Product Name Alternative

3α,7α,12α,25-Tetrahydroxycoprostane

UNSPSC

12352211

Target

Endogenous Metabolite; G protein-coupled Bile Acid Receptor 1

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

O[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCCC(C)(O)C)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)O)([H])C1)C)O)C

Molecular Formula

C27H48O4

Molecular Weight

436.67

References & Citations

[1]Iguchi Y, et al. Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor. J Lipid Res. 2010 Jun;51 (6) :1432-41.|[2]DeBarber AE, et al. Newborn screening for cerebrotendinous xanthomatosis is the solution for early identification and treatment. J Lipid Res. 2018 Nov;59 (11) :2214-2222.