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Tri (GalNAc-PEG2) -PEG4-cyclo (Ac-DCAW-{Arg (3F-Ph) -PEG2}-LGELVWCT) (Cys2-Cys12)

Tri (GalNAc-PEG2) -PEG4-cyclo (Ac-DCAW-{Arg (3F-Ph) -PEG2}-LGELVWCT) (Cys2-Cys12) is an asialoglycoprotein receptor (ASGPR) ligand that can be used for LYsosome TArgeting Chimera (LYTAC) research[1].

Product Specifications

UNSPSC

12352203

Target

Asialoglycoprotein Receptor (ASGPR) ; LYTACs

Related Pathways

Immunology/Inflammation; PROTAC

Field of Research

Others

Purity

99.46

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N1)=O)C(C)C)=O)CC(C)C)=O)CCC(O)=O)=O)=O)CC(C)C)=O)CC(NCC2=CC(F)=C(C=C2)OC(CCOCCOCCNC(CCOCCOCCOCCOCCC(NCC(NC(COCCC(NCCOCCOCCO[C@H]3[C@@H]([C@H]([C@H]([C@H](O3)CO)O)O)NC(C)=O)=O)(COCCC(NCCOCCOCCO[C@H]4[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)NC(C)=O)=O)COCCC(NCCOCCOCCO[C@H]5[C@@H]([C@H]([C@H]([C@H](O5)CO)O)O)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)C)=O)NC([C@@H](NC(C)=O)CC(O)=O)=O)C(N[C@H](C(O)=O)[C@H](O)C)=O)[C@@H]1CC8=CNC9=CC=CC=C89

Molecular Formula

C152H236FN25O62S2

Molecular Weight

3488.76

References & Citations

[1]Dubowchik G M, et al. Bifunctional degraders of galactose-deficient immunoglobulins. WO2024228935A1. 2024-11-07.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

ADC Related

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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