Glycerophosphoinositol 4-phosphate

Glycerophosphoinositol 4-phosphate (GroPIns-4-P) is a metabolite of phospholipase A and an inhibitor of adenylylcyclase. Glycerophosphoinositol 4-phosphate can regulate cAMP-dependent cellular functions. Glycerophosphoinositol 4-phosphate can also induce the formation of membrane ruffles and stress fibers in serum-starved Swiss 3T3 cells by activating the small GTPases Rac and Rho, respectively. Glycerophosphoinositol 4-phosphate can be used in research on cancer cell motility and invasiveness[1][2].

Product Specifications

CAS Number

[129830-96-2]

Product Name Alternative

GroPIns-4-P

UNSPSC

12352211

Target

Adenylate Cyclase; ROCK

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad

Field of Research

Cancer

Smiles

O[C@@H]1[C@H]([C@@H]([C@H]([C@@H]([C@@H]1O)OP(OC[C@@H](CO)O)(O)=O)O)O)OP(O)(O)=O

Molecular Formula

C9H20O14P2

Molecular Weight

414.19

References & Citations

[1]Mancini R, et al. Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4-phosphate. Mol Biol Cell. 2003 Feb;14 (2) :503-15.|[2]Iacovelli L, et al. Glycerophosphoinositol 4-phosphate, a putative endogenous inhibitor of adenylylcyclase. J Biol Chem. 1993 Sep 25;268 (27) :20402-7.