1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium)
1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) (1-Arachidonoyl-sn-glycerol 3-phosphate (sodium) ) is a phospholipid with arachifonic acid at the sn-1 position. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) binds to the LPA2/EDG4 receptor (EC50 of 10 nM) . 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can be found in rat brain as 37% of the arachidoinic acid-containing lysophosphatidic acid species. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) is the precursor to 1-arachidonoyl glycerol. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can prevent TNF-α and IL-6 secretion in wild type LPS-stimulated dendritic cells. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) reduces differentiation of HT-29 colon carcinoma cells into goblet cells when sodium butyrate is present[1][2][3][4].
Product Specifications
Product Name Alternative
1-Arachidonoyl-sn-glycerol 3-phosphate (sodium) ; 1-Arachidonoyl LPA (sodium) ; LPA (20:4) (sodium)
UNSPSC
12352128
Target
LPL Receptor
Related Pathways
GPCR/G Protein
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O[C@H](COC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COP(O)(O[Na])=O
Molecular Formula
C23H38NaO7P
Molecular Weight
480.51
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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