N-Sterol
N-Sterol is a sterol lipid that has been used to generate lipid nanoparticles (LNPs) for delivery of mRNA in vitro and in vivo. N-Sterol LNPs are taken up in J774A.1 macrophages in a lipid composition-dependent manner via clathrin caveolae, caveolin-mediated endocytosis, micropinocytosis, or phagocytosis at different frequencies[1].
Product Specifications
CAS Number
[3069417-18-8]
UNSPSC
12352211
Target
Liposome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
O=C(/C=C/N(CCOC)C)O[C@H]1CC[C@@]2([C@]3(CC[C@@]4([C@]([H])(CC[C@]4([C@@]3(CC=C2C1)[H])[H])[C@@H](CCCC(C)C)C)C)[H])C
Molecular Formula
C34H57NO3
Molecular Weight
527.82
References & Citations
[1]Narasipura EA, et al. A Chemoinformatic-Guided Synthesis of a Spleen-Expressing mRNA Lipid Nanoparticle Platform. Bioconjug Chem. 2025 Jan 15;36 (1) :54-65.
Shipping Conditions
Room temperature
Scientific Category
Oligonucleotides
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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