BCP-NC2-C12
BCP-NC2-C12 is an ionizable cationic lipid. BCP-NC2-C12 can be used to generate lipid nanoparticles (LNPs) for in vivo delivery of mRNA. BCP-NC2-C12 LNPs mediated an approximately 90% reduction in PCSK9 serum protein levels via CRISPR/Cas9 gene knockout[1].
Product Specifications
UNSPSC
12352211
Target
Liposome
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Smiles
O=C(C12CC(C(NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC)=O)(C2)C1)NCCN(CCCCCCCCCCCC)CCCCCCCCCCCC
Molecular Formula
C59H116N4O2
Molecular Weight
913.58
References & Citations
[1]Wu S, et al. Isosteric 3D Bicyclo[1.1.1]Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing. J Am Chem Soc. 2024 Dec 18;146 (50) :34733-34742.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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