BI-5756
BI-5756 is a CETP inhibitor and cannabinoid receptor 1 (CB1) agonist. BI-5756 can significantly increase HDL-C levels and reduce LDL-C levels. BI-5756 can also enhance the function of regulatory T cells while maintaining T cell-mediated anti-tumor activity. BI-5756 can directly inhibit the growth of tumor cells and upregulate the expression of MHC I, MHC II, and CD80 on tumor cells. BI-5756 has a protective effect in graft-versus-host disease models. BI-5756 can be used in research on tumors, graft-versus-host disease, and metabolic diseases[1].
Product Specifications
CAS Number
[1332485-18-3]
UNSPSC
12352005
Target
Cannabinoid Receptor; CETP; MHC
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Smiles
CC(C1=NC(CC(C)(C[C@@H]2O)C)=C2C3=C1[C@@H](C4=CC=C(C=C4)C(F)(F)F)OC35CCOCC5)C
Molecular Formula
C27H32F3NO3
Molecular Weight
475.54
References & Citations
[1]Kim S, et al. BI-5756 Reduces Graft-Versus-Host Disease Through CB1-Mediated Treg Upregulation. Molecules. 2025 Aug 28;30 (17) :3517.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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